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KMID : 1140920230470050358
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Annals of Rehabilitation Medicine
2023 Volume.47 No. 5 p.358 ~ p.366
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Improved Muscle Mass and Function With Protein Supplementation in Older Adults With Sarcopenia: A Meta-Analysis
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Kwon Hyo-Eun
Ko Na-Yeon
Yuk Do-Young
Choi Seo-Won
Koh Seong-Eun
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Abstract
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Objective : To systematically review the effects of protein supplementation in older adults with sarcopenia.
Methods : A systematic literature search was conducted in PubMed, Cochrane Library, and Embase databases until May 2023. The inclusion criteria were as follows: (1) randomized controlled trials with a quantitative study design; (2) studies with a study group of older adults with sarcopenia; (3) studies comparing muscle mass, muscle strength, and performance of older adults with sarcopenia after protein supplementation; and (4) studies published up to May 2023.
Results : Six retrospective comparative studies, including 715 patients, met the inclusion criteria. The nutritional supplementation group exhibited significant improvement in appendicular skeletal muscle mass (standardized mean difference [SMD]=0.41; 95% confidence interval [CI], 0.24?0.58; p<0.001; I2=1%), while handgrip strength (SMD=0.37; 95% CI, -0.32?1.07; p=0.29; I2=94%) and Short Physical Performance Battery (SPPB) (SMD=0.35; 95% CI, -0.47?1.18; p=0.40; I2=94%) showed a tendency for improvement.
Conclusion : Nutritional supplementation with protein increased appendicular muscle mass in older adults with sarcopenia and improved handgrip strength and SPPB scores.
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KEYWORD
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Sarcopenia, Protein, Skeletal muscle, Meta-analysis
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